The University of Niš is the member of the
- European University Association (EUA),
- Inter-University Center in Dubrovnik (IUC),
- Virtual University of the Adriatic-Ionian Basin "UniAdrion",
- Danube Rectors' Conference (DRC),
- European Foundation of Quality in E-Learning (EFQUEL),
- Alps-Adriatic Rectors Conference(AARC),
- Francophone University Association (AUF),
- Association of Economic Universities of South and Eastern Europe and the Black Sea Region (ASECU),
- COST Action CA15113: Science and Management of Intermittent Rivers and
Ephemeral Streams (SIMERS), Faculty of Sciences and Mathematics, University of Niš.